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Feature Products |
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Cell Biologists often need to detect and quantitate
intracellular spectroscopically silent ions such as Cl - , Na +
, K + , or Ca 2+ . Detection of these ions is most often accomplished
by using sensing probes or dyes. These dyes typically consist of
a fluorophore and a chelator that confers analyte specificity,
such as azacrown ether for Na+ or K+ or a BAPTA group for Ca 2+
. Intracellular Ca 2+ levels modulate a number of different cellular
processes. While extracellular concentrations of calcium are generally
quite high, 3-4 mM, those inside the cell are tightly controlled
and generally kept at or below 1 µM. |
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Calcium can enter the general cytoplasm of cells from either the
extracellular fluid or by release from intracellular stores depending
on the use. The calcium required for neurotransmitter release from
nerve terminals comes from extracellular sources, while muscle contractions
use calcium from intracellular stores. In regards to the triggering
event to mobilize calcium movement there are a variety of mechanisms
for calcium entry. Ligand-gated and G-protein coupled channels are
the most common means of calcium entry. These channels are a heterogeneous
group of proteins, which have been distinguished into different classes
based on their pharmacological and physiological properties. |
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Current Promotions |
Fanbo Biochemicals is currently offering 25%
discount for all its reactive dyes that include EDANS, FITC,
FAMs and rhodamines.
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